It seems interesting to consider the relationship between Depression and meditation from this perspective, the way they can both be internalizing, "alienating" in a sense, detaching.
Actually this book has a take on Depression that I found fascinating, because it's formulated as a sympathetic critique of David Foster Wallace's philosophy, as expressed most clearly in his commencement speech This Is Water.
I loved DFW very much since I was in high school. Then in university, while I myself knew struggles with Depression, I read his short story The Depressed Person which is remarkably bleak and honest, especially about how the depressed person can know that they are burdening their friends, that they are in some way being very selfish, and how this deepens the Depression even further: this recursion of dark self-centered alienation.
Then DFW develops a kind of philosophy of becoming happy by deciding to see everything as sacred, in a way... which didn't help against his own clinical Depression. And Dreyfus sees this philosophy as fatally flawed, for basically phenomenological reasons related to the perception of salience.
If the phenomenal aspect is damaged, like in Depression, effort and training in virtue will be difficult and unrewarding.